If your search string looks like this: "john, doe".
Then this:
www.something.com/search.php?s=john%2+doe,
should look like this:
www.something.com/search.php?s=john%2C+doe
You are using the GET method.
and you should be receiving the data using:
And $some_variable should be used in your query
Or like this:
I setup the same scenario in my database, and it works just fine.
If you can't figure it out from this information, then you will need to post
your code if you want us to figure out the problem.