This video script is the easiest to setup on lighttpd, it has support for this webserver and the rewrite rules. Admin also writes a lot of tutorials for this webserver and helps setup if needed.
The admin panel is amazing since the latest update 1.4.3, the best thing is it's free and plugins like massimport and server2server are very cheap (10 euro)
I hope the frontend will be improved the next months because that needs some work... as a designer I found it easy to make changes to the template.
If your looking for a free video script that has support for lighttpd and apache this is it.