I've come to rely on Dodo Upload from time to time. I've found it one of the easiest to configure upload scripts around. Sure, Flash upload scripts have more bells and whistles, but who has time to install and configure them these days. If you need a simple upload script, go for Dodo.
FYIW :: I had no trouble changing the uploads location. In fact, I made quite a few edits to the script to suit my needs. Here is a demo as proof: